Submitted by jec3011 on March 17, 2023 - 6:12pm
| Title | S100 chemokines mediate bookmarking of premetastatic niches. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Rafii S, Lyden D |
| Journal | Nat Cell Biol |
| Volume | 8 |
| Issue | 12 |
| Pagination | 1321-3 |
| Date Published | 2006 Dec |
| ISSN | 1465-7392 |
| Keywords | Animals, Calgranulin A, Calgranulin B, Cell Movement, Chemokines, Gene Expression Regulation, Neoplastic, Lung Neoplasms, Mice, Neoplasm Metastasis, RNA, Messenger |
| Abstract | Primary tumours release soluble factors, including VEGF-A, TGFβ and TNFα, which induce expression of the chemokines S100A8 and S100A9 in the myeloid and endothelial cells within the lung before tumour metastasis. These chemokine-activated premetastatic niches support adhesion and invasion of disseminating malignant cells, thereby establishing a fertile habitat for metastatic tumours. |
| DOI | 10.1038/ncb1206-1321 |
| Alternate Journal | Nat Cell Biol |
| PubMed ID | 17139281 |
| PubMed Central ID | PMC2955889 |
| Grant List | P01 HL059312-090006 / HL / NHLBI NIH HHS / United States P01 HL067839-020004 / HL / NHLBI NIH HHS / United States R01 HL061849-04 / HL / NHLBI NIH HHS / United States P01 HL072942-010004 / HL / NHLBI NIH HHS / United States R01 HL058707-04 / HL / NHLBI NIH HHS / United States P01 HL072942 / HL / NHLBI NIH HHS / United States P01 HL067839 / HL / NHLBI NIH HHS / United States R01 HL058707-03 / HL / NHLBI NIH HHS / United States R01 HL061849-03S1 / HL / NHLBI NIH HHS / United States P01 HL059312-060006 / HL / NHLBI NIH HHS / United States R01 HL061849-05 / HL / NHLBI NIH HHS / United States P01 HL059312-080006 / HL / NHLBI NIH HHS / United States R01 HL075234 / HL / NHLBI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States P01 HL067839-040004 / HL / NHLBI NIH HHS / United States P01 HL059312 / HL / NHLBI NIH HHS / United States R01 HL061849-03 / HL / NHLBI NIH HHS / United States R01 HL061849 / HL / NHLBI NIH HHS / United States P01 HL067839-050004 / HL / NHLBI NIH HHS / United States P01 HL067839-030004 / HL / NHLBI NIH HHS / United States P01 HL059312-070006 / HL / NHLBI NIH HHS / United States P01 HL067839-010004 / HL / NHLBI NIH HHS / United States R01 HL075234-01 / HL / NHLBI NIH HHS / United States R01 HL061849-02 / HL / NHLBI NIH HHS / United States |