Publications

Lucotti S, Ogitani Y, Kenific CM, Geri J, Kim YHun, Gu J, Balaji U, Bojmar L, Shaashua L, Song Y et al..  2025.  Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2.. Cell.

Overbey EG, Ryon K, Kim JK, Tierney BT, Klotz R, Ortiz V, Mullane S, Schmidt JC, MacKay M, Damle N et al..  2024.  Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).. Nat Commun. 15(1):4964.

Searles SC, Chen W-S, Yee JD, Lee P, Lee CK, Caron C, Neto F, Matei I, Lyden D, Bui JD.  2024.  MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti-tumour immunity.. J Extracell Vesicles. 13(10):e12515.

Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbrügger U et al..  2024.  Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.. J Extracell Vesicles. 13(2):e12404.

Jones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C, Ryon K, Tierney B, Damle N, MacKay M, Afshin EE et al..  2024.  Molecular and physiological changes in the SpaceX Inspiration4 civilian crew.. Nature. 632(8027):1155-1164.

Bojmar L, Zambirinis CP, Hernandez JM, Chakraborty J, Shaashua L, Kim J, Johnson KEnnu, Hanna S, Askan G, Burman J et al..  2024.  Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer.. Nat Med. 30(8):2170-2180.

Wan Z, Gu J, Balaji U, Bojmar L, Molina H, Heissel S, Pagano AE, Peralta C, Shaashua L, Ismailgeci D et al..  2024.  Optimization of ultracentrifugation-based method to enhance the purity and proteomic profiling depth of plasma-derived extracellular vesicles and particles.. J Extracell Biol. 3(7):e167.

Bojmar L, Kim HSang, Sugiura K, Heissel S, Lucotti S, Cioffi M, Johnson KEnnu, Cohen-Gould L, Zhang H, Molina H et al..  2024.  Protocol for cross-platform characterization of human and murine extracellular vesicles and particles.. STAR Protoc. 5(1):102754.

Nanaware PP, Khan ZN, Clement CC, Shetty M, Mota I, Seltzer ES, Dzieciatkowska M, Gamboni F, D'Alessandro A, Ng C et al..  2024.  Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.. Cell Rep. 43(6):114311.

Kim JK, Tierney BT, Overbey EG, Dantas E, Fuentealba M, Park J, S Narayanan A, Wu F, Najjar D, Chin CR et al..  2024.  Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.. Nat Commun. 15(1):4954.

Overbey EG, Kim JK, Tierney BT, Park J, Houerbi N, Lucaci AG, Medina SGarcia, Damle N, Najjar D, Grigorev K et al..  2024.  The Space Omics and Medical Atlas (SOMA) and international astronaut biobank.. Nature. 632(8027):1145-1154.

Dror S, Lucotti S, Asao T, Li J, Wortzel I, Berger LShaashua, Matei I, Boudreau N, Zhang H, Jones D et al..  2024.  Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential.. Res Sq.

Wortzel I, Seo Y, Akano I, Shaashua L, Tobias GCardial, Hebert J, Kim K-A, Kim DA, Dror S, Liu Y et al..  2024.  Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression.. Nat Cancer. 5(12):1815-1833.

Liu S, Benito-Martín A, Vatter FAPelissie, Hanif SZ, Liu C, Bhardwaj P, Sethupathy P, Farghli AR, Piloco P, Paik P et al..  2023.  Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism.. bioRxiv.

Lengel HB, Mastrogiacomo B, Connolly JG, Tan KSee, Liu Y, Fick CN, Dunne EG, He D, Lankadasari MB, Satravada BAnusha et al..  2023.  Genomic mapping of metastatic organotropism in lung adenocarcinoma.. Cancer Cell.

Patras L, Shaashua L, Matei I, Lyden D.  2023.  Immune determinants of the pre-metastatic niche.. Cancer Cell. 41(3):546-572.

Kenari ANasiri, Bojmar L, Heissel S, Molina H, Lyden D, Hoshino A.  2023.  Protocol for Plasma Extracellular Vesicle and Particle Isolation and Mass Spectrometry-Based Proteomic Identification.. Methods Mol Biol. 2628:291-300.

Dai J, Cimino PJ, Gouin KH, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A et al..  2022.  Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.. Nat Cancer. 3(1):25-42.

Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W et al..  2022.  BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.. Nat Commun. 13(1):6513.

Choi J, Cho HYeon, Jeon J, Kim K-A, Han YDae, Ahn JBae, Wortzel I, Lyden D, Kim HSang.  2022.  Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer.. Front Oncol. 12:1067210.

Strillacci A, Sansone P, Rajasekhar VK, Turkekul M, Boyko V, Meng F, Houck-Loomis B, Brown D, Berger MF, Hendrickson RC et al..  2022.  ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance.. NPJ Breast Cancer. 8(1):96.

Lucotti S, Kenific CM, Zhang H, Lyden D.  2022.  Extracellular vesicles and particles impact the systemic landscape of cancer.. EMBO J. 41(18):e109288.

Lyden D, Ghajar CM, Correia ALuísa, Aguirre-Ghiso JA, Cai S, Rescigno M, Zhang P, Hu G, Fendt S-M, Boire A et al..  2022.  Metastasis.. Cancer Cell. 40(8):787-791.

Khan I, Gril B, Hoshino A, Yang HH, Lee MP, Difilippantonio S, Lyden DC, Steeg PS.  2022.  Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems.. Clin Exp Metastasis. 39(5):815-831.

Shor RE, Dai J, Lee S-Y, Pisarsky L, Matei I, Lucotti S, Lyden D, Bissell MJ, Ghajar CM.  2022.  The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings.. Mol Oncol. 16(1):130-147.