Publications

Zarnegar S, Durham BH, Khattar P, Shukla NN, Benayed R, Lacouture ME, Lavi E, Lyden DC, Diamond EL, Dunkel IJ et al..  2018.  Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis.. Pediatr Blood Cancer. 65(1)

Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS et al..  2018.  A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma.. Pediatr Blood Cancer. 65(1)

Parks MM, Kurylo CM, Dass RA, Bojmar L, Lyden D, C Vincent T, Blanchard SC.  2018.  Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.. Sci Adv. 4(2):eaao0665.

Zhang H, Lyden D.  2017.  Bone voyage-Osteoblasts remotely control tumors.. Science. 358(6367):1127-1128.

Sansone P, Berishaj M, Rajasekhar VK, Ceccarelli C, Chang Q, Strillacci A, Savini C, Shapiro L, Bowman RL, Mastroleo C et al..  2017.  Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles.. Cancer Res. 77(8):1927-1941.

Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K et al..  2017.  Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells.. Clin Cancer Res. 23(12):3109-3119.

Hoshino A, Lyden D.  2017.  Metastasis: Lymphatic detours for cancer.. Nature. 546(7660):609-610.

Sansone P, Savini C, Kurelac I, Chang Q, Amato LBenedetta, Strillacci A, Stepanova A, Iommarini L, Mastroleo C, Daly L et al..  2017.  Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.. Proc Natl Acad Sci U S A. 114(43):E9066-E9075.

Becher OJ, Gilheeney SW, Khakoo Y, Lyden DC, Haque S, De Braganca KC, Kolesar JM, Huse JT, Modak S, Wexler LH et al..  2017.  A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors.. Pediatr Blood Cancer. 64(7)

Becher OJ, Millard NE, Modak S, Kushner BH, Haque S, Spasojevic I, Trippett TM, Gilheeney SW, Khakoo Y, Lyden DC et al..  2017.  A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.. PLoS One. 12(6):e0178593.

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y et al..  2017.  Pre-metastatic niches: organ-specific homes for metastases.. Nat Rev Cancer. 17(5):302-317.

Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim J-H, Gorge E, Yanowitch R, Cope W, Vartanian E et al..  2017.  A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma.. J Clin Invest. 127(5):1826-1838.

Matei I, Kim HSang, Lyden D.  2017.  Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis.. Cell. 170(2):223-225.

Giles AJin, Reid CMarie, Evans JDeWayne, Murgai M, Vicioso Y, Highfill SLorenz, Kasai M, Vahdat L, Mackall CLee, Lyden D et al..  2016.  Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre-metastatic Niche.. Cancer Res. 76(6):1335-47.

André Mdo Rosári, Pedro A, Lyden D.  2016.  Cancer Exosomes as Mediators of Drug Resistance.. Methods Mol Biol. 1395:229-39.

A Morrissy S, Garzia L, Shih DJH, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FMG, Ramaswamy V, Lindsay PE et al..  2016.  Divergent clonal selection dominates medulloblastoma at recurrence.. Nature. 529(7586):351-7.

Becker A, Thakur BKumar, Weiss JMitchell, Kim HSang, Peinado H, Lyden D.  2016.  Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.. Cancer Cell. 30(6):836-848.

Gao SP, Chang Q, Mao N, Daly LA, Vogel R, Chan T, Liu SHui, Bournazou E, Schori E, Zhang H et al..  2016.  JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.. Sci Signal. 9(421):ra33.

Kenific CM, Nogués L, Lyden D.  2016.  Pre-Metastatic Niche Formation Has Taken Its TOLL.. Cancer Cell. 30(2):189-191.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J et al..  2016.  Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.. Nat Commun. 7:10442.

Papaspyridonos M, Matei I, Huang Y, Andre Mdo Rosario, Brazier-Mitouart H, Waite JC, Chan AS, Kalter J, Ramos I, Wu Q et al..  2015.  Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.. Nat Commun. 6:6840.

Wang X, Dubuc AM, Ramaswamy V, Mack S, Gendoo DMA, Remke M, Wu X, Garzia L, Luu B, Cavalli F et al..  2015.  Medulloblastoma subgroups remain stable across primary and metastatic compartments.. Acta Neuropathol. 129(3):449-57.

Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BKumar, Becker A, Hoshino A, Mark MTesic, Molina H et al..  2015.  Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.. Nat Cell Biol. 17(6):816-26.

Hoshino A, Costa-Silva B, Shen T-L, Rodrigues G, Hashimoto A, Mark MTešić, Molina H, Kohsaka S, Di Giannatale A, Ceder S et al..  2015.  Tumour exosome integrins determine organotropic metastasis.. Nature. 527(7578):329-35.

Thakur BKumar, Zhang H, Becker A, Matei I, Huang Y, Costa-Silva B, Zheng Y, Hoshino A, Brazier H, Xiang J et al..  2014.  Double-stranded DNA in exosomes: a novel biomarker in cancer detection.. Cell Res. 24(6):766-9.