Publications

Li Z, Low V, Luga V, Sun J, Earlie E, Parang B, Ganesh KShobana, Cho S, Endress J, Schild T et al..  2022.  Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.. Nat Commun. 13(1):6239.

Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW et al..  2021.  Calcium signaling induces a partial EMT.. EMBO Rep. 22(9):e51872.

Grunberg N, Pevsner-Fischer M, Goshen-Lago T, Diment J, Stein Y, Lavon H, Mayer S, Levi-Galibov O, Friedman G, Ofir-Birin Y et al..  2021.  Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles.. Cancer Res. 81(7):1639-1653.

Kenific CM, Zhang H, Lyden D.  2021.  An exosome pathway without an ESCRT.. Cell Res. 31(2):105-106.

Bojmar L, Kim HSang, Tobias GC, Vatter FAPelissie, Lucotti S, Gyan KEnnu, Kenific CM, Wan Z, Kim K-A, Kim DA et al..  2021.  Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids.. STAR Protoc. 2(1):100225.

Vatter FAPelissie, Cioffi M, Hanna SJ, Castarede I, Caielli S, Pascual V, Matei I, Lyden D.  2021.  Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses.. J Exp Med. 218(8)

Jones GD, Brandt WS, Shen R, Sanchez-Vega F, Tan KSee, Martin A, Zhou J, Berger M, Solit DB, Schultz N et al..  2021.  A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma.. JAMA Surg. 156(2):e205601.

Jones GD, Caso R, Tan KSee, Mastrogiacomo B, Sanchez-Vega F, Liu Y, Connolly JG, Murciano-Goroff YR, Bott MJ, Adusumilli PS et al..  2021.  KRAS G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma.. Clin Cancer Res. 27(9):2604-2612.

García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AAmor et al..  2021.  Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.. Nat Cancer. 2(12):1387-1405.

Wang G, Zhang H, Lyden D.  2021.  Tumour-regulated anorexia preceding cachexia.. Nat Cell Biol. 23(2):111-113.

Bezdan D, Grigorev K, Meydan C, Vatter FAPelissie, Cioffi M, Rao V, MacKay M, Nakahira K, Burnham P, Afshinnekoo E et al..  2020.  Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers.. iScience. 23(12):101844.

Hoshino A, Kim HSang, Bojmar L, Gyan KEnnu, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S et al..  2020.  Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.. Cell. 182(4):1044-1061.e18.

Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F et al..  2020.  A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.. Cell Stem Cell. 27(1):125-136.e7.

Zimmer AS, Steinberg SM, Smart DDee, Gilbert MR, Armstrong TS, Burton E, Houston N, Biassou N, Gril B, Brastianos PK et al..  2020.  Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases.. Future Oncol. 16(14):899-909.

Zhang H, Lyden D.  2019.  Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization.. Nat Protoc. 14(4):1027-1053.

Wortzel I, Dror S, Kenific CM, Lyden D.  2019.  Exosome-Mediated Metastasis: Communication from a Distance.. Dev Cell. 49(3):347-360.

Gupta MP, Tandalam S, Ostrager S, Lever AS, Fung AR, Hurley DD, Alegre GB, Espinal JE, H Remmel L, Mukherjee S et al..  2019.  Non-reversible tissue fixation retains extracellular vesicles for in situ imaging.. Nat Methods. 16(12):1269-1273.

Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, Petersen J, Guo Y, Parks MM, Kurylo CM et al..  2019.  Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.. Nat Commun. 10(1):2110.

Kataru RP, Ly CL, Shin J, Park HJu, Baik JEun, Rehal S, Ortega S, Lyden D, Mehrara BJ.  2019.  Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments.. Cancer Immunol Res. 7(8):1345-1358.

Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HSang, Oxley PR, Scandariato I, Casanova-Salas I et al..  2019.  Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.. Nat Cell Biol. 21(11):1403-1412.

Rodrigues G, Zhang H, Lyden D.  2019.  Tumour vesicular micromachinery uncovered.. Nat Cell Biol. 21(7):795-797.

Wittkowski KM, Dadurian C, Seybold MP, Kim HSang, Hoshino A, Lyden D.  2018.  Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer.. PLoS One. 13(7):e0199012.

Matei I, Rampersaud S, Lyden D.  2018.  Engineered niches model the onset of metastasis.. Nat Biomed Eng. 2(12):885-887.

Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G et al..  2018.  Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer.. HPB (Oxford). 20(7):597-604.

Zhang H, Freitas D, Kim HSang, Fabijanic K, Li Z, Chen H, Mark MTesic, Molina H, Martin ABenito, Bojmar L et al..  2018.  Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.. Nat Cell Biol. 20(3):332-343.