Highlighted Publications

Lucotti S, Ogitani Y, Kenific CM, Geri J, Kim YH, Gu J, Balaji U, Bojmar L, Shaashua L, Song Y, Cioffi M, Lauritzen P, Joseph OM, Asao T, Grandgenett PM, Hollingsworth MA, Peralta C, Pagano AE, Molina H, Lengel HB, Dunne EG, Jing X, Schmitter M, Borriello L, Miller T, Zhang H, Romin Y, Manova K, Paul D, Remmel HL, O'Reilly EM, Jarnagin WR, Kelsen D, Castellino SM, Giulino-Roth L, Jones DR, Condeelis JS, Pascual V, Bussel JB, Boudreau N, Matei I, Entenberg D, Bromberg JF, Simeone DM, Lyden D. Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2. Cell. 2025 Feb 11:S0092-8674(25)00094-7. doi: 10.1016/j.cell.2025.01.025. Epub ahead of print. PMID: 39938515.

Wortzel I, Seo Y, Akano I, Shaashua L, Tobias GC, Hebert J, Kim KA, Kim D, Dror S, Liu Y, Azrak GC, Cioffi M, Johnson KE, Hennika T, Twerski MZ, Kushner A, Math R, Han YD, Han DH, Jung M, Park J, Paik S, Shin JS, Lee MG, Russo MV, Zakheim D, Barnes J, Mehta S, Manova K, Schwartz RE, Thakur BK, Boudreau N, Matei I, Zhang H, Sidoli S, Bromberg J, David Y, Kim HS, Lyden D. Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression. Nat Cancer. 2024 Dec;5(12):1815-1833. doi: 10.1038/s43018-024-00862-6. Epub 2024 Dec 3. PMID: 39627554.

Jones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C,....& Mason CE. Molecular and physiological changes in the SpaceX Inspiration4 civilian crew. Nature. 2024 Aug;632(8027):1155-1164. doi: 10.1038/s41586-024-07648-x. Epub 2024 Jun 11. PMID: 38862026; PMCID: PMC11357997. Highlighted in: (2024) Space Omics and Medical Atlas (SOMA) across orbits Nature Portfolio

Wan Z, Gu J, Balaji U, Bojmar L, Molina H, Heissel S, Pagano AE, Peralta C, Shaashua L, Ismailgeci D, Narozniak HK, Song Y, Jarnagin WR, Kelsen DP, Bromberg J, Pascual V, Zhang H. Optimization of ultracentrifugation-based method to enhance the purity and proteomic profiling depth of plasma-derived extracellular vesicles and particles. J Extracell Biol. 2024 Jul 23;3(7):e167. doi: 10.1002/jex2.167. PMID: 39045341; PMCID: PMC11263976.

Bojmar L, Kim HS, Sugiura K, Heissel S, Lucotti S,...& Hoshino A. Protocol for cross-platform characterization of human and murine extracellular vesicles and particles. STAR Protoc. 2024 Mar 15;5(1):102754. doi: 10.1016/j.xpro.2023.102754. Epub 2023 Dec 13. PMID: 38096060; PMCID: PMC10762520.

Bojmar, L., Zambirinis, C. P., Hernandez, J. M., Chakraborty, J., Shaashua, L., Kim, J., ... & Lyden, D. Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer. Nat Med. 2024 Aug;30(8):2170-2180. doi: 10.1038/s41591-024-03075-7. Epub 2024 Jun 28. PMID: 38942992.

Patras L, Shaashua L, Matei I, Lyden D. Immune determinants of the pre-metastatic niche. Cancer Cell. 2023 Mar 13;41(3):546-572. doi: 10.1016/j.ccell.2023.02.018. PMID: 36917952.

Wang, G., Li, J., Bojmar, L., Chen, H., Li, Z., Tobias, G. C., ... & Lyden, D. Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature. 2023 Jun;618(7964):374-382. doi: 10.1038/s41586-023-06114-4. Epub 2023 May 24. PMID: 37225988; PMCID: PMC10330936.

García-Silva, S., Benito-Martín, A., Nogués, L., Hernández-Barranco, A., Mazariegos, M. S., Santos, V., ... & Peinado, H. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat Cancer. 2021 Dec;2(12):1387-1405. doi: 10.1038/s43018-021-00272-y. Epub 2021 Nov 25. PMID: 34957415; PMCID: PMC8697753.

Pelissier Vatter FA, Cioffi M, Hanna SJ, Castarede I, Caielli S, Pascual V, Matei I, Lyden D. Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. J Exp Med. 2021 Aug 2;218(8):e20202579. doi: 10.1084/jem.20202579. Epub 2021 Jun 28. PMID: 34180950; PMCID: PMC8241538.

Hoshino, A., Kim, H. S., Bojmar, L., Gyan, K. E., Cioffi, M., Hernandez, J., ... & Lyden, D. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Aug 20;182(4):1044-1061.e18. doi: 10.1016/j.cell.2020.07.009. Epub 2020 Aug 13. PMID: 32795414; PMCID: PMC7522766.

Rodrigues, G., Hoshino, A., Kenific, C. M., Matei, I. R., Steiner, L., Freitas, D., ... & Ly Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol. 2019 Nov;21(11):1403-1412. doi: 10.1038/s41556-019-0404-4. Epub 2019 Nov 4. PMID: 31685984; PMCID: PMC7354005.

Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-Mediated Metastasis: Communication from a Distance. Dev Cell. 2019 May 6;49(3):347-360. doi: 10.1016/j.devcel.2019.04.011. PMID: 31063754.

Zhang H, Lyden D. Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization. Nat Protoc. 2019 Apr;14(4):1027-1053. doi: 10.1038/s41596-019-0126-x. Epub 2019 Mar 4. PMID: 30833697; PMCID: PMC6733524.

Zhang, H., Freitas, D., Kim, H. S., Fabijanic, K., Li, Z., Chen, H., ... & Lyden, D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. PMID: 29459780; PMCID: PMC5931706.

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017 May;17(5):302-317. doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17. PMID: 28303905.

Sansone, P., Savini, C., Kurelac, I., Chang, Q., Amato, L. B., Strillacci, A., ... & Bromberg, J. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9066-E9075. doi: 10.1073/pnas.1704862114. Epub 2017 Oct 11. Erratum in: Proc Natl Acad Sci U S A. 2017 Nov 13;: PMID: 29073103; PMCID: PMC5664494.

Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. Cancer Cell. 2016 Dec 12;30(6):836-848. doi: 10.1016/j.ccell.2016.10.009. PMID: 27960084; PMCID: PMC5157696.

Hoshino, A., Costa-Silva, B., Shen, T. L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., ... & Lyden, D. Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Nov 19;527(7578):329-35. doi: 10.1038/nature15756. Epub 2015 Oct 28. PMID: 26524530; PMCID: PMC4788391.

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., ... & Lyden, D. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015 Jun;17(6):816-26. doi: 10.1038/ncb3169. Epub 2015 May 18. PMID: 25985394; PMCID: PMC5769922.

Thakur, B. K., Zhang, H., Becker, A., Matei, I., Huang, Y., Costa-Silva, B., ... & Lyden, D. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 2014 Jun;24(6):766-9. doi: 10.1038/cr.2014.44. Epub 2014 Apr 8. PMID: 24710597; PMCID: PMC4042169.

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., ... & Lyden, D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012 Jun;18(6):883-91. doi: 10.1038/nm.2753. Erratum in: Nat Med. 2016 Dec 6;22(12 ):1502. PMID: 22635005; PMCID: PMC3645291.

Psaila B, Lyden D. The metastatic niche: adapting the foreign soil. Nat Rev Cancer. 2009 Apr;9(4):285-93. doi: 10.1038/nrc2621. PMID: 19308068; PMCID: PMC3682494.

Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., ... & Lyden, D. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005 Dec 8;438(7069):820-7. doi: 10.1038/nature04186. PMID: 16341007; PMCID: PMC2945882.